In 1765 he worked with William M'Alpine as a publisher/bookseller on Marlborough Street.
[3][4] In 1770 he attempted to issue "the first bible ever printed in America.
"[5] In late 1770 or early 1771 he published an account of the trial following the Boston Massacre.
[6][7] Fleeming sailed from Boston in 1773 on a ship that allegedly carried "a quantity of silver to the amount of 30,000 dollars ... from the Custom House here, being part of the revenue money which has so long been complained of as being unconstitutionally taken from us.
He later travelled to the United States "as an agent for a commercial house.