John Fletcher Little (1843 – 9 August 1914) was an Irish physician and Liberal Party politician.

[1] Fletcher was influenced by Silas Weir Mitchell's physical methods of treatment such as massage and visited the United States.

[1] Little studied at Cambridge and Charing Cross Hospital.

[1] With Sir Jonathan Hutchinson he started the London post-graduate scheme which developed into the Medical Graduates' College and Polyclinic.

[1] Little was inspired by James Salisbury's diet treatment and reported in 1886 that he had spent six weeks living on a diet of lean meat and hot water which made him lose a stone in weight.