He is best known for his news illustrations, beginning with his work for the Pittsburgh Press when he covered the 1889 Johnstown flood.
Born in Corinth, West Virginia, he married Ida Van Dyke in 1893, around the same time he moved to Chicago.
His illustrations were displayed in three different exhibitions at the Art Institute of Chicago.
Holme created the Bandar Log Press in 1895, which published books such as Just For Fun, Swanson, Able Seaman, and Strenuous Lad’s Library.
He briefly lived in Phoenix, Arizona, in an effort to treat tuberculosis, but after a relapse, attempted to relocate to Denver, where he died in 1904.