John Griffin Carlisle (September 5, 1834 – July 31, 1910) was an American attorney and Democratic Party politician from Kentucky.

After Carlisle's term as Lieutenant governor ended in 1875, he ran for and won a seat in the United States House of Representatives for Kentucky's 6th district.

[2]"[H]e is the ablest man they have on that side of the House," said his Republican rival and successor Thomas Brackett Reed, "[b]ut no Speaker could do any better with his hands tied by the rules we are working under.

In May 1890, the Kentucky legislature elected Carlisle to the United States Senate to fill the nearly four years remaining in the unexpired term of the late Sen. James B. Beck.

In response to a run on the American gold supply, Carlisle felt forced to end silver coinage.

[1] By May 1899, the North American Trust Company had directors such as John G. Carlisle, Adlai E. Stevenson, and Wager Swayne.

[5] He moved to New York City, where he practiced law, and died on July 31, 1910, at age 75, and is buried in Linden Grove Cemetery in Covington, Kentucky.