William Henry Wadsworth (July 4, 1821 – April 2, 1893) was a U.S. Representative from Kentucky.

Born in Maysville, Kentucky, Wadsworth attended town and county private schools.

He studied law and graduated from Augusta College, Bracken County, Kentucky, in 1841.

During the Civil War Wadsworth served as aide to General Nelson, with the rank of colonel, at the Battle of Ivy Mountain.

He was appointed United States commissioner to Mexico, under the treaty of Washington for the adjustment of claims, by President Grant in 1869.