Giorno's creative journey was marked by collaborations, groundbreaking initiatives, and a deep exploration of diverse art forms.

He gained prominence through his association with pop art luminary Andy Warhol, sparking a creative partnership that propelled his career to new heights.

His notable appearance in Warhol's 1964 film Sleep, where he slept on camera for over five hours, introduced audiences to his unique blend of performance and artistic expression.

This venture allowed individuals to access brief poems by contemporary poets via telephone, forging a novel connection between technology and poetry.

Collaboration was a hallmark of Giorno's work, as he joined forces with renowned artists, including William S. Burroughs, Patti Smith, Laurie Anderson, Philip Glass, and Robert Mapplethorpe.

As Giorno's career progressed, his work began to incorporate political themes, notably his active protests against the Vietnam War.

In 1967, Giorno organized the first Dial-A-Poem event at the Architectural League of New York, making short poems by various contemporary poets available over the telephone.

From 1976 to 1979, Giorno also hosted The Poetry Experiment[8] and presented his eight-part series Dial-A-Poem Poets, with Charles Ruas, on WBAI-Pacifica Radio.

[9] Giorno's text-based poetry evolved rapidly in the late 1960s from direct appropriation of entire texts from newspapers, to montage of radically different types of textual material, to the development of his signature double-column poems, which feature extensive use of repetition both across columns and down the page.

The poems also feature increasingly radical political content, and Giorno was involved in a number of protests against the Vietnam War.

(1982) with Glenn Branca,[10] is prominently featured in Ron Mann's 1982 film Poetry in Motion, and is heard in performance with guitarist Rudolph Grey in the opera Agamemnon (1993).

[11] Giorno stopped using the found elements of the Readymades of Marcel Duchamp tradition in his poetry in the early 1980s and henceforth pursued a kind of experimental realism, using lyrical incantation and minimalist art-like repetition.

Giorno's artwork Poem Prints (1991) is included in the permanent collection of the Pérez Art Museum Miami, Florida.