He joined Dutch club Feyenoord on loan for the 2011–12 season where he scored 20 goals in 23 games before a virus ended his time in the Netherlands.

Having represented Sweden at several youth levels, Guidetti earned his first senior international cap against Croatia on 29 February 2012.

After one year with the Impala club, Guidetti joined Mathare United's academy, the MYSA organisation for sports development aid, in the slums of Nairobi.

I still have a strong link with Kenya and every time I go back there I always get a warm welcome.In April 2008, at the age of sixteen, Guidetti signed a three-year deal with Manchester City.

[10] Manchester City's manager at the time, Sven Goran Eriksson, spotted Guidetti's talent in his native Sweden, and immediately signed him.

[12] During this American tour, Guidetti managed to make his debut for the Manchester City first team, coming on as a sub in the second half in a match against Sporting Lisbon.

"[22][23][24] The Dutch football association FBO (Federatie Betaald Voetbal Organization), let a lawyer review the preliminary agreement between John Guidetti and Twente.

We look forward to welcoming John for his first practice 1 July", said Twente chairman Joop Munsterman to Voetbal International magazine.

[35] This happened to be the third consecutive hat-trick in an Eredivisie home game, becoming the second player in the history of the league to achieve this after Cees Groot did this in 1963.

The opponents then equalized three minutes before the end, and Guidetti later apologized to the team, the supporters and the coach, saying it was "one of the worst moments in my life".

[38] Due to this red card, Guidetti missed the important game in the title challenge against PSV Eindhoven the following week.

Guidetti then missed the rest of the Eredivisie season, as well as UEFA Euro 2012, after losing all feeling in his right leg while suffering from a mystery virus.

[41] Guidetti, who watched from home the game against SC Heerenveen which clinched second place, was then carried on the shoulders of some Feyenoord fans towards De Kuip stadium to celebrate this achievement.

Guidetti was back at Man City for the start of 2012–13, but spent most of the season struggling to recover from the virus that curtailed his spell at Feyenoord.

[53] After not playing in Stoke's next match against Chelsea in the FA Cup, Guidetti vented his frustration towards manager Mark Hughes to the Swedish media.

[56] On 4 September 2014, Guidetti joined Scottish Premiership side Celtic on loan for the 2014–15 season,[57] but was ineligible for the UEFA Europa League group stages.

[61] He scored a hat-trick on 29 October, as Celtic advanced to the semi-finals of the Scottish League Cup with a 6–0 win over Partick Thistle.

[67] However, on as a second-half substitute in the UEFA Europa League match against Inter Milan on 19 February, he rescued a 3–3 draw for Celtic with a stoppage-time equaliser,[69] controlling a lobbed pass onto his chest before volleying into the roof of the net.

[69] On 15 March, Guidetti won his first silverware at Celtic, as they defeated Dundee United 2–0 in the League Cup Final at Hampden Park.

[71] On 19 April, in a Scottish Cup semi-final at Hampden Park, he came on for Griffiths in extra time and equalised against Inverness, although Celtic eventually lost 2–3.

[75] On 11 July 2015, Guidetti signed for La Liga club Celta Vigo on a free transfer, after agreeing to a five-year contract.

[77] On 27 January 2016, Guidetti scored with a 25-metre volley in a 3–2 win over Atlético Madrid in the quarter-finals of the Copa del Rey, helping his side reach the semi-finals of the Cup for the first time in 15 years.

At the 2015 European Under-21 Championship in the Czech Republic, Guidetti equalised as Sweden came from behind to defeat Italy 2–1 in their opening group game in Olomouc.

[91] He had to wait over 2+1⁄2 years for his second cap, replacing Isaac Thelin for the last 23 minutes of a 1–0 friendly defeat to France in Marseille on 18 November 2014.