John H. "Jack" Byrne (born 1946) an American neuroscientist, is the Virgil and June Waggoner Chair of Neurobiology and Anatomy[1] at McGovern Medical School in Houston, Texas.

After completing his Ph.D. at NYU, and a post-doctoral fellowship at Columbia, Byrne joined the faculty at the Department of Physiology at the University of Pittsburgh School of Medicine, where he investigated the ink motor reflex of Aplysia californica.

Byrne served as professor and chair of the Department of Neurobiology and Anatomy at McGovern Medical School from 1987 to 2017.

Byrne’s research interests over the past 40 years have focused on elucidating the neural and molecular mechanisms of memory by exploiting the technical advantages of Aplysia californica.

His lab uses an interdisciplinary approach that ranges from behavioral to molecular levels, including computational modeling and attempts to relate higher-level phenomena to lower-level mechanisms.