John Harnett Noseworthy (born 9 November 1951) is an American neurologist who served as the president and chief executive officer of Mayo Clinic from 2009 to 2018.

In 1983, he completed research fellowships in pathology at Harvard Medical School, and in neurology at Massachusetts General Hospital.

[10] As CEO, he reorganized Mayo Clinic from a holding company into a single unit with one business plan and strategy.

[16] He also oversaw Mayo Clinic's launch of its Destination Medical Center, a 20-year $5.6 billion economic development initiative.

[15] Noseworthy advised the first Trump administration on health care issues, including ways to improve the Department of Veterans Affairs,[18] national medical research funding, and the effects of immigration policies on patient access and doctor training.

[19] Additionally, Noseworthy has advocated for telemedicine as a means to improve health care access and lower costs.