He was the eldest son of Sir John Hamilton of Lettrick and his wife Jean, daughter of Alexander Campbell, Bishop of Brechin.
[1] Hamilton was created Lord Bargany in the Peerage of Scotland on 16 November 1641 and was served heir to his father on 23 April 1642.
[4] He supported King Charles I during the Civil War, and raised a regiment of foot for the Duke of Hamilton's expedition into England in 1648.
He then joined King Charles II in the Netherlands, and during the 1651 invasion of England was sent to raise troops in the north of Scotland.
After Charles was defeated at Worcester Bargany was again taken prisoner, and held in the Tower of London for about a year.