John Hepburn (died after 20 July 1525) was a Scottish cleric.
The son of Patrick Hepburn, 1st Lord of Hailes, he was Prior of Saint Andrews.
He also briefly held the ward of Patrick Hepburn, 3rd Earl of Bothwell his great nephew.
His other relation Patrick Hepburn (not to be confused with the Earl) succeeded him in the priory in 1525.
[Scots Peerage] He was elected as Archbishop of St. Andrews but his appointment was turned down by the Pope.