He was also the Whig Party nominee in first Wisconsin gubernatorial election, where he lost to Nelson Dewey.

[1] He graduated from Yale University in 1834, where he was a member of the secret society Skull and Bones.

Tweedy was prominent in business involving railroads and public affairs.

He died in Milwaukee, Wisconsin, aged 77, and was buried in Danbury, Connecticut.

[3][4] His son, John H. Tweedy, Jr., donated his papers to the Wisconsin Historical Society.