He bought his first drum kit at the age of 16[1] and started pursuing an interest in music in a Dame Alice Owen's School band called The Cut with Gary Kemp, Tony Hadley and Steve Norman in 1976.

In 1999, John Keeble, along with fellow band members Tony Hadley and Steve Norman, attempted to sue former Spandau Ballet guitarist, Gary Kemp, for alleged unpaid royalties.

On 25 March 2009, he joined the rest of his original classic-line-up bandmates for a press conference at HMS Belfast, to announce that the band had reformed and would conduct a world tour starting in Dublin in October 2009.

[7] Keeble played drums for Fish, the former lead singer of Marillion, during his first-ever solo show in the Rex Cinema at Lockerbie on 21 March 1989.

[citation needed] He performed on his single "State of Mind", the third track on his debut solo album Vigil in a Wilderness of Mirrors.