John Thomas Keefe (July 16, 1867 – August 10, 1937) was an American left-handed pitcher in Major League Baseball who played for the American Association Syracuse Stars in 1890.

Born in Fitchburg, Massachusetts, he attended the College of the Holy Cross.

In his only big league season, Keefe went 17 and 24 with a 4.32 earned run average in 43 games for the unimpressive 55 and 72 Stars.

As a batter, Keefe collected 30 hits in 157 at-bats for a .191 batting average.

This biographical article relating to an American baseball pitcher born in the 1860s is a stub.