In 2011, he made his Broadway debut in the musical revival of Frank Loesser's How to Succeed in Business Without Really Trying alongside Daniel Radcliffe.

On February 13, 2024, while talking to reporters, Larroquette admitted feeling a little sad when he first walked on the set of the Night Court revival, due to being one of the only cast members from the original run still living.

The show has a loyal cult following, although the series has never received an official home video release from Warner Bros.

His portrayal of Joey Heric, a wealthy, wisecracking, narcissistic psychopath with a habit of stabbing his gay lovers to death, won him his fifth Emmy Award.

He also guest-starred in the drama House where he played a previously catatonic father awakened to try to save his son.

[11] His starring roles include the 1989 film Second Sight with Bronson Pinchot, and Madhouse with Kirstie Alley.

Other films in which Larroquette had significant roles include: Blind Date, Stripes, Meatballs Part II, Summer Rental, Star Trek III: The Search for Spock, JFK, and Richie Rich.

Larroquette made his musical stage debut in the Los Angeles production of How the Grinch Stole Christmas!

[12] He appeared on Broadway in a revival of Gore Vidal's The Best Man, starring James Earl Jones, Angela Lansbury, and Candice Bergen.

In early 2019, he was back in New York City starring in the play Nantucket Sleigh Ride by John Guare, at the Lincoln Center Theatre.

In this off-beat play, Larroquette portrayed the lead character, Edmund "Mundie" Gowery, for a three-month run.

[8] Cookson brought her daughter Lisa from a previous relationship into the marriage, and she and Larroquette would have two sons together, Jonathan and Benjamin.