[2] Born in Lake, Mississippi, Littlejohn first learned to play the blues from Henry Martin, a friend of his father's.
In 1946 he left home and traveled widely, spending time in Jackson, Mississippi; Arkansas; Rochester, New York; and Gary, Indiana.
[3] He settled in Gary in 1951, playing whenever possible in the nearby Chicago area.
Littlejohn played regularly in Chicago clubs (he was filmed by drummer Sam Lay playing with Howlin' Wolf's band about 1961) but did not make any studio recordings until 1966, when he cut singles for several record labels.
He died of renal failure in Chicago, on February 1, 1994, at the age of 62.