John Louis of Isenburg-Offenbach (German: Johann Ludwig von Isenburg-Offenbach, 14 February 1622 — 23 February 1685) was the Count Isenburg-Offenbach from 1635 until 1685, and the co-Count of Isenburg-Birstein from 1641 until 1685.
John Louis married Louise, daughter of Louis Henry, Prince of Nassau-Dillenburg, on 10 February 1646.
They had five children:
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