John Mottrom (died 1655), or Mottram, was one of the first, if not the first, white settlers in the Northern Neck region of Virginia between 1635 and 1640.
their daughter, married Thomas Willoughby, whose sister, Elizabeth Willoughby, married first, Simon Oversee, second, Major George Colclough [third husband of her sister-in-law's mother, Ursula (Bysshe) Thompson Mottrom Colclough].
George Colclough died very soon after their marriage and Elizabeth then married Isaac Allerton, Jr.,[2] a trustee of the will of Mottrom's son-in-law Col. Nicholas Spencer.
[5] Daughter Frances Mottrom was married to Col. Nicholas Spencer,[6] Secretary and President of the Council and later acting Governor of the Virginia Colony (1683–1684) and patentee of the land at Mount Vernon with John Washington.
Mottrom was probably the first Englishman to settle on the Virginia side of the Potomac River, and his retreat was a refuge for Protestants fleeing Lord Calvert's Catholic Maryland.