The John Nance Garner House, located in Uvalde, Texas, United States, was the home of American Vice-President John Nance Garner and his wife Ettie from 1920 until Ettie's death in 1948.

The structure is a two-story, H-shaped, hip-roofed, brick house with white trim around doors and windows, and brown shingles on the roof.

[3] It was built to plans by Atlee B. Ayres, at the time the most prominent architect in San Antonio, if not the state.

On November 20, 1999, the City of Uvalde transferred ownership of the Garner Home and Museum to the University of Texas at Austin, whereupon it became a division of the Dolph Briscoe Center for American History.

The displays were moved to the First State Bank of Uvalde main branch lobby.