John Nau Penisini (born May 31, 1997) is an American professional football nose tackle who is a free agent.

[5] During the 2017 season, Penisini played in 12 games, including one start, where he recorded four tackles and one sack.

During the 2018 Pac-12 Football Championship Game, he recorded three tackles and a blocked field goal in a 3–10 loss to Washington.

[6] During the 2019 season, Penisini played in all 14 games, with 13 starts, where he recorded seven tackles-for-loss, two sacks, two forced fumbles and 38 tackles.

[13] In Week 11 against the Carolina Panthers, Penisini recorded his first career sack on P. J. Walker during the 20–0 loss.