[3][4] These accomplishments, highlighted in independent reviews,[10][11][12][13] were followed by Falck's development of synthetic EET and 20-HETE functional analogs/antagonists, which were of critical importance during the subsequent characterization of physiological and pathophysiological roles for these enzymes and their metabolites.
[14][15][16] Falck is known for his application of efficient, eco-friendly chemical procedures and/or strategies during the synthesis of a wide range of drug candidates, several of which are currently undergoing clinical evaluation.
He has also confirmed the structures of several bioactive compounds found in natural products, and of short-lived intracellular second messengers that mediated cellular responses to environmental stimuli.
Falck's contributions range from practical methods for creating carbon-carbon,[17][18] carbon-nitrogen,[19][20][21] and carbon-oxygen [22] bonds to the visualization of acidic organelles inside cells.
[23] He is also distinguished for developing the Falck-Bradsher annulation [24] used to prepare six-membered rings containing a nitrogen based upon a process chemists call an inverse electron demand [4+2]-cycloaddition.