John Ruiz vs. James Toney was a professional boxing match contested on April 30, 2005, for the WBA heavyweight championship.

After Roy Jones, Jr. elected to return to fighting as a light heavyweight, an interim championship match was signed between former world champions Ruiz and Hasim Rahman.

Ruiz won the fight, and after Jones decided not to return to the heavyweight division the WBA promoted him to full champion; Ruiz joined the list of fighters to have regained a piece of the heavyweight title after previously losing it, which at the time consisted of him, Evander Holyfield, Lennox Lewis, Michael Moorer, Mike Tyson, George Foreman, Tim Witherspoon, Muhammad Ali, and Floyd Patterson.

Toney knocked down the four-year reigning champion in the final round en route to a unanimous decision victory, taking a major world title in a third weight class.

Several days after the fight, it was revealed that in a post-fight urine test, the anabolic steroid nandrolone was detected in Toney's sample.