He was admitted at St Catharine's College, Cambridge on 4 July 1709[1] and became a merchant trading with Turkey.
He married Elizabeth Forester, daughter of Sir William Forester, MP of Dothill Park, Shropshire and his wife Mary Cecil, daughter of James Cecil, 3rd Earl of Salisbury in May or June 1717.
At the 1727 general election, he was returned as a Whig MP for Wenlock on the interest of his brother-in-law, William Forester.
All his known votes were against the Government, which made it appear that he was a Tory, so that in 1733 Lord Bradford, the leader of the Shropshire Whigs, openly opposed his re-election.
The local Tories offered to support him anyway, but the arguments of Sambrooke that his behavior was not exceptional for a Whig, and the attempts of Forester to persuade Bradford otherwise were unsuccessful.