The Reverend John Simpson (1740–1808), was a Presbyterian minister and Whig leader in the American Revolution.
He graduated Princeton College with high honors in 1763, and was licensed to preach by the Presbytery of New Brunswick, New Jersey in 1770.
In 1774 he was installed at Chester County, South Carolina and preached at upper and lower Fishing Creek and Bethesda.
Due to Simpson's actions[clarification needed] at Alexander's Old Field and Mobley's, the Loyalist commander Christian Huck came to capture Simpson at Fishing Creek Church on June 11, 1780; finding no one there he burned the church and killed William Strong.
In 1790 Simpson moved to Pendleton District and continued his ministerial work until his death in 1808 at Roberts Presbyterian Church.