[1][2] His research on the regulation of the cardiovascular system included "classic studies on reflex control of the circulation, haemodynamic responses to heat stress and exercise, and mechanisms of vasodilation.
In the department of physiology he had four close colleagues, namely Archibald David Mant Greenfield (1917–2005), Ian Campbell Roddie (1928–2011), Walter Ernest "Darty" Glover (1932–2017), and Robert Ford "Bob" Whelan (1922–1984), who later became deans of medical schools.
[1] In 1957 he emigrated with his family to the United States and joined the staff of the Mayo Clinic, where he remained until his retirement in 1989.
[3] Shepherd was elected in 1951 a member of The Physiological Society[3] and in 1977 a fellow of the Royal College of Physicians.
[1] Upon his death, John T. Shepherd was survived by his second wife, Marion, as well as his daughter and son from his first marriage, and "four step-children, five grandchildren, eight step-grandchildren and a great-grandson.