John Vaughan (born 1525, died 1574) was a Welsh politician.
He was the eldest son of Hugh Vaughan of Kidwelly.
He was elected a Member (MP) of the Parliament of England for Carmarthen Boroughs in 1558 and 1571, and Carmarthenshire in 1572.
He married Catherine, the daughter of Henry Morgan of Muddlescwm, with whom he had two sons, Henry and Walter, and one daughter.
This article about a Member of the Parliament of England (before 1707) representing a Welsh constituency is a stub.