He was the eldest son and heir of the 3rd Viscount de Vesci (d. 1875) by his wife, Lady Emma Herbert (1819–1884), youngest daughter of the 11th Earl of Pembroke.
[2] On 8 November 1884, he was created Baron de Vesci, of Abbey Leix in the Queen's County, in the Peerage of the United Kingdom, thus giving him an hereditary seat in the House of Lords.
On 4 June 1872 he married Lady Evelyn Charteris, eldest daughter of the 10th Earl of Wemyss by his wife, Lady Anne Frederica Anson, by whom he had one daughter and sole heiress: He died in 1903 leaving no sons, so his British peerage became extinct, while his Irish titles were inherited by his nephew, Yvo Vesey, 5th Viscount de Vesci.
[4] His personal estate in England and Ireland was valued at £44,247; in his Will he confirmed a £10,000 Settlement on his daughter Mary.
His estates in Kent, Dublin, Cork and Limerick were placed in Trust to his nephew and successor to Viscountcy, Ivo Richard Vesey, and thereafter to Ivo's male-line descendants; this property was charged with annuties for his daughter, widow, and sister Beatrice Vesey, as well as an additional £10,000 to be settled on his daughter in the event that she married.