[3] In a related line of study, Wikswo collaborated with Vanderbilt Professor John Barach to analyze the information content of biomagnetic versus bioelectric signals.
With Nestor Sepulveda, Wikswo use the finite element method to calculate the distinctive fourfold symmetric magnetic field pattern produced by an outwardly propagating wave front.
Again using the finite element model, Wikswo, Roth and Sepulveda predicted the transmembrane potential distribution around a unipolar electrode passing current into a passive, two-dimensional sheet of cardiac tissue.
[12] The calculation of the transmembrane potential by a unipolar electrode resulted in another prediction: regions of hyperpolarization adjacent to the cathode in the direction parallel to the myocardial fibers.
[14] In the 1990s, Wikswo began developing high spatial resolution SQUID magnetometers for mapping the magnetic field, to use in both biomagnetic studies and in non-destructive testing.
[15] [16] [17] As is characteristic of Wikswo's work, he simultaneously developed theoretical methods to image a two-dimensional current density distribution from magnetic field measurements.
This work led to a second R&D 100 Award for the MultiWell MicroFormulator, which delivers and removes cell culture media to each of the 96 wells of a microwell plate for toxicology research.