He was a member of the long-established Wyse family of St John's Manor, who settled in the city shortly after the Norman conquest of Ireland.
[2] John's best-known descendant was Sir Thomas Wyse (1791-1862), the politician, diplomat and nephew by marriage of Napoleon.
[3] In 1482 he received a special licence to leave Ireland to study law at the Inns of Court in London, as Ireland had no law school at the time, and it was necessary for Irish lawyers who hoped to achieve judicial office to receive their legal training in this way.
[1] He was replaced by the English-born Walter Ivers, as part of a general purge of Irish judges in 1494: many of them, though not as far as is known Wyse himself, were suspected of disloyalty to the Tudor dynasty, and in particular of supporting the pretender to the Crown, Perkin Warbeck.
Wyse was forced to flee;[1] he subsequently put in a claim to the Treasury for the loss of two horses and received compensation.