Hendren attended Northeast High school and later played college football for Bucknell University.

[1] He was named captain of the team in 1917 but went on to serve with the Army in France during World War I[2] where he was wounded in action.

[4] He later played professionally in the National Football League (NFL) with the Canton Bulldogs in 1920 and the Cleveland Indians in 1921.

Hendren scored his lone professional touchdown while playing for the latter team, during a 17–0 victory over the New York Brickley Giants.

He died in 1964 at the Delaware County Memorial Hospital at the age of 67.