Born in Clifton Forge, Virginia, he played for the Cleveland Indians, Chicago White Sox, and Philadelphia Phillies.

[1] Humphries played college baseball at North Carolina.

[3] He made 45 pitching appearances as a rookie in 1938 to lead the American League, beating out Bobo Newsom of the St. Louis Browns by one.

[5] As of 2020[update], no other pitcher had ever pitched more than nine innings in more than three consecutive appearances.

This biographical article relating to an American baseball pitcher born in the 1910s is a stub.