in Empire Records (1995), as Donny Ray Black in Francis Ford Coppola's The Rainmaker (1997), as Vernon Gant in Limitless (2011), as Blackout in the Marvel superhero film Ghost Rider: Spirit of Vengeance (2011), and as Cage Wallace in The CW's series The 100.

But following that he moved to Los Angeles with his mother and at the age of 15 started his acting career with a guest appearance on Party of Five in 1994.

Whitworth had a recurring role on the CBS crime drama CSI: Miami, where he played bad-boy Detective Jake Berkeley, a love interest of Calleigh Duquesne.

The story line swiftly made Whitworth's character a controversial one, as his competition for Duquesne was long-time CSI agent Eric Delko.

He also played the villain Blackout in the 2011 film Ghost Rider: Spirit of Vengeance and Griffin Cavenaugh in the thriller Pathology.