Its students primarily reside inside the city of Johns Creek, though the school also serves part of Alpharetta.

[2] In 2013, Johns Creek was ranked by Newsweek as one of America's best public high schools, #214 in the nation, #5 in the State of Georgia and #2 in Fulton County.

Johns Creek is in Region 6 in Class AAAAAA with geographic rivals Chattahoochee High School, located 2.5 miles away, and Lambert High School, located in nearby Forsyth County.

Many of the athletes were a part of the Chattahoochee "Joe Volpe" feeder programs and played on the same youth sports teams prior to the existence of Johns Creek.

In 2010 the Johns Creek Volleyball team made the AAAA Final Four before losing to eventual state champion, Pope High School.