[2] In the comics industry, his works include J. M. DeMatteis' graphic novel Moonshadow, Grant Morrison's The Mystery Play,[3] Neil Gaiman's The Sandman: The Wake[4][5] with Michael Zulli and Charles Vess, Mike Carey's Lucifer: Nirvana and Swamp Thing: Roots.

[6] He worked with writers Walt and Louise Simonson and co-artist Kent Williams on Havok and Wolverine: Meltdown in 1988.

[7] Muth received an Eisner Award in the category "Best Painter/Multimedia Artist (Interior Art)" in 1995 for his work on The Mystery Play.

[8] In addition, Muth has had an award-winning career as a children's book writer and illustrator.

In 2005, Muth collaborated with author Caroline Kennedy on A Family of Poems: My Favorite Poetry for Children.