In November 1997, he won the IBF Intercontinental Light-Welterweight title, beating Rimvidas Bilius of Lithuania on points.
In February 2002, he fought Eamonn Magee for the Commonwealth light-welterweight title, losing when the fight was stopped in the sixth.
In March 2007, he defended the British lightweight title against Scott Lawton, winning by a technical knockout in the seventh.
In October 2007, he defended the British lightweight title again, this time against Dave Stewart, winning by a technical knockout in the twelfth round.
On 4 October 2008, Thaxton captured the vacated European lightweight title in the third round of the contest against Spaniard Juan Carlos Melero Diaz.