He has been involved in internet based telemedicine applications [1] and is an editor of the RDDL specification for XML Namespaces.
[2] Borden's earliest work used artificial intelligence techniques to model neurochemical networks in the brain.
[3][4][5] At Tufts-New England Medical Center he developed the Borden Classification of Dural Arteriovenous Fistulas.
He is an advisor for the Science Directorate of NASA, has been an invited expert for the World Wide Web Consortium Web Ontology Working Group and has been actively involved in the development and standardization of XML based electronic medical records.
[10] More recently Dr. Borden has been involved in research studies aimed at repairing degenerated intervertebral discs using growth factors,[11][self-published source?]