[1] He subsequently changed his professional name back to his birth name, later recalling, "It always made me feel bad for my father, who never caused me any grief about it.... As my career grew and my son was born, I changed my name back to my real name, Goldsmith, so my father could enjoy his son's success and have a grandson to carry his name as well.

[1] Goldsmith also made guest appearances on 45 television series, including Gunsmoke; Bonanza; Adam-12; Knight Rider; CHiPs; Eight Is Enough; The Rockford Files; Hawaii Five-O; Barnaby Jones; MacGyver; Murder, She Wrote; Charlie's Angels; Petrocelli; Manimal; The Fall Guy; Dynasty; T.J. Hooker; Hardcastle and McCormick; Magnum, P.I.

In 2011 he and his wife Barbara (who was his agent when he obtained the Dos Equis role) moved to a house in the area of Manchester, Vermont.

[6] Beginning in April 2007 and continuing through 2015, Goldsmith was featured in a high-profile television ad campaign, promoting Dos Equis beer.

[7] The campaign, which transformed Goldsmith into "the most interesting man in the world", was credited for helping to fuel a 15.4 percent sales increase for the brand in the United States in 2009 and also made him into a very popular meme.

"[10] In September 2016, French actor Augustin Legrand (who also speaks English and Spanish) became the new "Most Interesting Man in the World".

[12][13] In the past, Goldsmith has been an advocate for landmine victim support and has assisted the Morris Animal Foundation in their efforts to prevent and cure cancer in dogs.