His father, Sidney Roosevelt Katz, was a secretary-treasurer for the AFL-CIO, and his mother, Julia, died at a relatively young age.

[10] Katz co-wrote House of Games with Mamet and had small roles in the Mamet-directed films Things Change, Homicide, The Spanish Prisoner and State and Main.

Now he speaks publicly as part of a tour sponsored by a manufacturer of medications used to treat MS.[16]"People have been pretty supportive; nobody ever had me in mind for an action film because of the kind of work I do -- mostly in the world of animation, which is not a big issue because as a person, I can't run that fast; as a cartoon character, I can fly -- literally.

His voice can also be heard in the animated series Home Movies,[11] a show with many ties to Dr. Katz, as well as on the Adult Swim animated comedy series Squidbillies where he performed uncredited voice-overs as "The Rapist" in Season 2 and as the Holodeck Therapist in Season 5.

[19] In 2007, Katz joked to Blast Magazine entertainment editor Bessie King about the success of his Comedy Central show and the recent release of the full series on DVD.

[4] In the spring of 2012, Katz taught a theater class at Brandeis University in Short Form Comedy.