On July 10, 1799, he married Anna Nye in her hometown of Hardwick, Massachusetts.
[2] In 1814, Makepeace was a signer of a petition that requested that Lynn's Second Parish be set off as a separate town known as Westport.
[4] The plan was abandoned, however the following year the Second Parish separated from Lynn and became the Town of Saugus.
Saugus' first Town Meeting was held on March 13, 1815, and Makepeace was appointed to the position of Sealer of Weights and Measurers and elected to the town's first Board of Selectmen, Assessors, and Overseers of the Poor as well as its first School Committee.
On August 9, 1829, Makepeace married Mary Stocker, of Saugus, Massachusetts.