Oquendo made his professional debut on June 25, 2004, scoring a third-round technical knockout (TKO) victory against Yuniel Ramos at the Civic Center in Kissimmee, Florida.
[2] After compiling a record of 14–1 (9 KOs) he faced future two-weight world champion Juan Manuel López for the WBO Latino junior featherweight title on February 23, 2008, at the Coliseo Héctor Solá Bezares in Caguas, Puerto Rico.
[3] He bounced back from defeat with three wins, two by stoppage, before making a second attempt at the WBO Latino title, facing Jose Angel Beranza on February 27, 2010, at the Coliseo Rubén Rodríguez in Bayamón, Puerto Rico.
[7] For his next fight he returned to the Coliseo Rubén Rodríguez, facing former world champion Wilfredo Vázquez Jr. for the vacant WBO International junior featherweight title on October 6, 2012.
The bout took place on December 5, 2015, at the Barclays Center in New York City, and served as part of the undercard for the Daniel Jacobs vs. Peter Quillin world title fight.
He scored two stoppage wins before fighting for his first title at the weight—the WBO-NABO junior lightweight title—against Jose Lopez on October 6, 2018, at the Puerto Rico Convention Center in San Juan.