Before entering private practice, Skrmetti served as a federal prosecutor for almost a decade, first with the Civil Rights Division of the U.S. Department of Justice, and then as an Assistant U.S. Attorney in Memphis[1] from 2011 to 2014.

[9] Skrmetti, as Chief Deputy Attorney General, argued against the then-planned Instagram for kids only, stating that the platform would be a means of having children become accustomed to social media when they are "psychologically vulnerable.

[14] Skrmetti contends that the manufacturers not only knew about the risk PFAs pose to both organisms and the environment, but that they also concealed the level of harm the chemicals could cause in order to raise their profits.

[16][17] Shortly after being sworn into office, AG Skrmetti issued a letter to the US Department of Education in opposition to adding "gender identity" to the wording of Title IX.

[21] The focus of the WV law is on transfemale athletes, claiming that their assigned gender at birth provides them an unfair advantage thus undoing the very protections established by Title IX.

[22] In March 2023, the LGBTQIA theatre company Friends of George's filed lawsuits against the State of Tennessee, AG Skrmetti, and Shelby County DA Steve Mulroy.

[34][35] Retired attorney Hannah Miyamoto (registered with the Hawaii bar) filed suit against Bill Lee, AG Skrmetti, and Davidson County DA Glenn R. Funk (all named) on March 8, 2023, in the Southern District of California, where she currently resides.

[36] She alleges that the TAEA, which AG Skrmetti has held is still in effect throughout Tennessee except in Shelby County,[37] prevents her from being able to perform her play, Twelve Nights with Viola and Olivia, in Nashville at TPAC.

[46] A statement from one of Ticketmaster's shareholders stated that the fiasco was caused by bots,[47] which may have put the company in violation of a 2008 bot-ban law passed in Tennessee.

"[54] Thirty-one states and the District of Columbia filed suit against AdoreMe.com in response to consumer complaints, alleging unfair trade practices against the retailer.

In May 2023, he was elected to the board of the Jason Foundation, Inc., a 501(c)(3) non-profit organization that attempts to provide support and educational tools for youth at risk of suicide.