[5] Tisch initiated the Loews Hotels Good Neighbor Policy over 20 years ago, one of the first of its kind in the hospitality industry.

For six years, he served as Chairman of NYC & Company, the city's official tourism marketing agency and convention and visitors bureau.

[8] In 2010, Tisch joined Jets owner Woody Johnson as co-chairs of the bid committee established to bring Super Bowl XLVIII to the New York/New Jersey metropolitan area,[8] which happened in 2014 when the Super Bowl was played at MetLife Stadium.

Tisch is the author of three books that explore his leadership philosophy, the role of the customer experience, and civic engagement: The Power of We: Succeeding Through Partnerships, Chocolates on the Pillow Aren't Enough: Reinventing the Customer Experience, and Citizen You: Doing Your Part to Change the World.

In March 2022, Tisch announced that he was making a contribution to his high school alma mater, The Frederick Gunn School, of $25 million to design and construct the Lizzie and Jonathan Tisch Center for Innovation and Active Citizenship.

[14] Tisch was elected chairman of the board of The Shed, a New York City arts center, in 2022.