He is known for his roles in the films The Virgin Suicides (1999), The Texas Chainsaw Massacre (2003), Hostage (2005), In the Valley of Elah (2007), The Ruins (2008), and Charlie's Angels (2019).

He has appeared in the television series The Black Donnellys (2007), Parenthood (2011–2013), Kingdom (2014–2017), Justified (2015), Snowfall (2018), Westworld (2018–2022), City on a Hill (2019), and Debris (2021).

[4] His aunt and uncle, Mary Evelyn Tucker and John Grim, founded and co-direct the Yale Forum on Religion and Ecology.

[13] In 2003, Tucker was cast in the much anticipated re-imagining of the 1974 horror film of the same name, The Texas Chainsaw Massacre produced by Michael Bay and directed by Marcus Nispel.

He played Jay, a mixed martial artist and son of trainer, Alvey Kulina,[21] for which he was nominated for Best Supporting Actor by Entertainment Weekly, which described his work as "one of the most electric performances on television.

"[22] In 2015, Tucker also appeared in the final five episodes of the TV series Justified on FX as the crazy-eyed Boon — a cross between Billy the Kid and Travis Bickle.

[23] Continuing his collaboration with Bryan Fuller, having appeared in the second season of Hannibal, Tucker starred as Low-Key Lyesmith in Starz's American Gods, adapted from Neil Gaiman's 2001 novel.

In 2021, Tucker played the lead role of CIA operative Bryan Beneventi in the short-lived NBC science fiction series Debris.