After graduating from Ann Arbor Pioneer High School in 1998, she attended the University of Michigan for her undergraduate studies, where she received her Bachelor of Science degree in biology in 2002.

[2][3] In April 2019, Khaldun assumed the position of Chief Medical Executive and Chief Deputy for Health at the Michigan Department of Health and Human Services, appointed by Governor Gretchen Whitmer in whose cabinet Khaldun also served.

[5] In her role at the Michigan Department of Health and Human Services (DHHS), Khaldun has served as the chief strategist for the state's response to the COVID-19 pandemic, including implementing measures to address racial disparities, as SARS-CoV-2 and the associated disease have disproportionately impacted communities of color across the nation.

[6] Under Khaldun's leadership, Michigan became one of the first states to release COVID-19 case data by race, which revealed that Black residents were overrepresented in diagnoses and deaths.

They have also expanded COVID testing and worked to build partnerships between impacted communities and health care providers.