The plot featured "creepy cyberbugs, techno-speak and computer-assisted info wars, all amidst good old-fashioned melodramatic evil.
In addition to the original character line-up, this story also features Race's daughter Jessie Bannon, introduced in Jonny's Golden Quest (1993) and voiced once again by Anndi McAfee.
The Atlanta Journal-Constitution declared Jessie to be "no 'icky girl'...Not only does she save Jonny's life when disturbingly large fire ants attack, but she also teaches him patience.
"[6] A test screening of Cyber Insects to 30- to 35-year-old males revealed that though some questioned her addition, most "understood that just like the [original] series, [the update] is a reflection of its times.
Jonny Quest and Hadji Singh are fleeing from a seemingly hostile tribe of natives in the Orinoco in South America.
Hadji points out that it is too easy, but Jonny impulsively attempts to take the jewel, and the two boys are taken prisoner by the tribe who have lain in wait.
Jonny reveals he is uncertain he can measure up his world-famous scientist father, and Atacama tells him if he follows the correct path he will attain his goal.
Dr. Quest is contacted by Commander Harris from the organization Intelligence 1, who reveals the bizarre weather is happening all over Earth and seeks his assistance in discovering its origin.
The Quests return to their South American base where Race's daughter Jessie rubs Jonny the wrong way due to his failing the Orinoquian test.
Armed with this information, Benton opts to go and visit his colleague Dr. Eve Belage, who works on Quest Station, a research platform in Earth's orbit.
However Jonny plays a recording of Chief Atacama's flute music, which drives the ants off, and Quest Shuttle 1 launches without incident.
After losing contact with his father, Jonny, accompanied by Race, Hadji, Jessie and Bandit, takes Quest Shuttle 2 into space to find them.
Aboard the asteroid, Zin explains he plans to weaken Earth using his weather-changing satellites before unleashing his cyber insects upon it.
When Jonny, desperate to save his father, flies Quest Shuttle 2 near the asteroid again, Zin has 427 send out fighters piloted by his cyber insects to destroy them.
Jonny blames himself for almost getting Race killed, but is told by Hadji and Jessie that part of growing up is making mistakes and learning from them.
Zin, intending to upload all of Benton and Eve's memories into his computer, hooks the two up to a brain-scanning machine before he is distracted by Quest Shuttle 2's attack.
Eve's assistant Mylana cryogenically freezes the piece of Assassinoid Bandit grabbed, and then Jonny and Race fight their way past the insects to reach Zin's unoccupied control room.
It begins to be destroyed as Jonny, Benton, Race and Eve try to reach Zin's escape ship, but it is damaged by an Assassinoid.