Soon after arriving at the launch site in Florida, the two girls find themselves going into space along with billionaire Sly Baron, trained astronaut Shannon Lucas, retired astronauts Zip Elvin and Colt Steelcase, alien hunting specialist Ridley, football player Uvininous "U-boat" Botango, news reporter Clark Sparkman (who instantly takes a fancy to Velma, much to her annoyance) and of course Fred, Shaggy and Scooby-Doo.

Shannon tells Daphne that she scored the highest on the space test she and her friends took, much to Velma's surprise.

After a while, a mysterious alien starts messing with the ship, causing it to land on Sly's space resort, situated on the dark side of the Moon.

She used her alien costume to make that happen and most of the other characters Scooby and his friends had met during the course of the movie to unknowingly go along in her plan.

She then realized that with Scooby and his friends abroad, they would prove the alien hoax and foil her scheme and had to make it hard for them to work together after she failed to convince them not to go in space.

She traps the heroes behind a wall of glass, telling them she planted explosive devices all over the resort to blow it up.

reveals that he isn't really a robot but a flesh and blood human actor when Daphne and Velma starts arguing again.

Upon hearing Velma's kind words of encouragement, Daphne manages to get the ship off the ground and fly everyone home.