He played his final season for the San Francisco 49ers in 2020 before retiring due to concussion-related health issues.

He led New London to an undefeated regular season in 2007, and was a finalist for the 2008 Joe Montana High School Quarterback of the Year.

[2] Reed committed to Florida over offers from Boston College, Connecticut, Duke, Iowa, Oregon, and Tennessee.

[10] After missing four consecutive games due to headaches after the concussion, he was placed on injured reserve on December 19, 2013.

[19] On September 13, 2015, Reed caught seven passes for 63 yards and his first touchdown of the season against the Miami Dolphins, a four-yarder.

[29][30] On December 26, 2015, Reed recorded 129 yards off of nine receptions and two touchdowns against the Philadelphia Eagles to win the NFC East.

[31] In his first playoff game, Reed recorded nine passes for 120 yards and one touchdown against the Green Bay Packers.

[41] On November 24, 2016, Reed caught a season-high ten passes for 95 yards and two touchdowns against the Dallas Cowboys.

[43][44] During the game, Reed suffered a Grade 3 AC joint separation in his left shoulder, keeping him out of the Week 13 matchup against the Arizona Cardinals.

[45] On December 20, 2016, in a game against the Carolina Panthers (in which Washington lost to Carolina), Reed was ejected after punching Panthers safety Kurt Coleman in the helmet; the subsequent penalty pushed Washington out of the red zone and forced them to make a field goal instead.

[47] Missing the majority of the 2017 season while dealing with a hamstring injury, Reed was placed on injured reserve on December 12, 2017.

[50] He suffered a toe injury in Week 14, missing the next two games before being placed on injured reserve on December 27, 2018.

[51] Reed suffered a concussion, the seventh of his career, during a third preseason game after a hit delivered by Atlanta Falcons safety Keanu Neal.

[60] Reed announced his retirement on April 20, 2021, citing health issues from the multiple concussions that he sustained during his career.