She studied drama at the Circle in the Square Theatre School in New York and was selected to join the Berlinale Talent Campus in Berlin.

[2] She studied at the Circle in the Square Theatre[3][4] School and briefly attended the Royal Academy of Dramatic Art[5][6] in London.

Co-star Annette O'Toole and Spiro played mother and daughter bounty hunters, based on the lives of Dottie And Brandi Thorson.

[9] She played the role of P.J., a twenty-something "guy's girl", and sports reporter who tries to find romance within her world that is dominated by male friends.

[10] Additional credits include The Year of Getting to Know Us, which premiered at the 2008 Sundance film festival, IFC's Alone with Her, as well as guest appearances on Cold Case,[11] Out of Practice,[12] and CSI: NY.

[13] Spiro was scheduled to star in the planned 2010–11 television series Love Bites, but fell out of the role in June 2010 due to other contractual obligations.