[12][13] Ayala pled guilty to three killings in 1993, but was believed to be responsible for roughly three dozen murders that took place during the Miami Drug War.

According to George Cadavid, a Miami police homicide detective, she wanted Castro dead after he had been hired to protect a drug supplier, but refused to carry out an unspecified order.

Ayala and Miguelito Perez drove up alongside Castro's vehicle while he was stopped at a red light and executed a drive-by shooting with a silenced machine gun.

[18] Acting on orders of Griselda Blanco, Ayala and his crew killed drug-dealing married couple Alfredo and Grizel Lorenzo in their South Miami home on May 26, 1982.

[19][20] According to Ayala, Griselda Blanco had originally ordered the murder of everyone in the house, but he made sure that the kids of Alfredo and Grizel Lorenzo were not harmed.

[7] Ayala made an agreement with Florida district attorney's office to testify against Griselda Blanco who had been charged with three counts of first-degree murder, but the case fell apart and was ultimately dismissed due to Ayala being involved in a phone sex scandal with two secretaries that worked in the state's attorney's office.