Jorge A. DePaula (born November 10, 1978) is a Dominican Republic former right-handed pitcher who pitched 27 innings in Major League Baseball in 2003–05.

On January 13, 1997, DePaula signed with the Colorado Rockies and pitched in their organization until April 20, 2001, when he was sent to the New York Yankees as the player to be named later for Craig Dingman.

However, after only one start and two relief appearances, it was clear that he needed Tommy John surgery, and did not pitch again at the major league level until September 2 of the next season.

In 2007, DePaula pitched in the Rockies organization again, playing for the Double-A Tulsa Drillers and Triple-A Colorado Springs Sky Sox.

On April 22, 2008, DePaula signed with the Edmonton Cracker-Cats of the Golden Baseball League.